Which of the following statements about sedative-hypnotics is true?

The statement regarding sedative-hypnotics potentially causing dependence with long-term use is indeed valid. Sedative-hypnotics, which include various classes of medications such as benzodiazepines and barbiturates, are often prescribed to manage conditions like anxiety, insomnia, and other sleep disorders. When these medications are used over an extended period, especially in higher doses, they can lead to physical and psychological dependence. This means that patients may find themselves requiring higher doses to achieve the same effect or may experience withdrawal symptoms if they stop taking the medication suddenly.

As for the other statements, sedative-hypnotics do not primarily target serotonin receptors; rather, they mainly affect gamma-aminobutyric acid (GABA) receptors, which are the primary inhibitory neurotransmitter systems in the brain. While sedative-hypnotics can help treat anxiety, describing their usage as "only" for anxiety treatment is misleading, as these drugs are also widely utilized for sleep induction and other conditions. Moreover, not all sedative-hypnotics are equally effective for sleep induction, as their pharmacokinetic profiles greatly differ, leading to variations in how quickly they induce sleep, their duration of action, and overall effectiveness in managing sleep disorders.