Which of the following is NOT true about MAO inhibitors?

The statement that MAO inhibitors selectively inhibit MAO-A only is not true. While some MAO inhibitors are selective for MAO-A, there are others that can inhibit both MAO-A and MAO-B. Non-selective MAO inhibitors affect both subtypes, which is important for their clinical use and interactions.

MAO-A is primarily responsible for the metabolism of norepinephrine and serotonin, while MAO-B is involved more with dopamine and phenylethylamine. Thus, non-selective MAO inhibitors can influence a broader range of neurotransmitter systems, leading to their varied therapeutic effects and potential side effects.

The other statements about MAO inhibitors are accurate reflections of their properties. For instance, they can indeed lead to hypertensive crises if foods rich in tyramine are consumed due to the inhibition of tyramine metabolism. Additionally, these medications help increase dopamine levels indirectly by preventing its breakdown. They also have the potential to interact with various other medications, making consideration of drug interactions crucial in clinical settings.