Which of the following drugs increases the action of GABA at the GABA receptors?

Prepare for the Pharmacology III – CNS Module Exam. Enhance your knowledge with detailed questions and thorough explanations. Excel in your exam!

Benzodiazepines are known to increase the action of GABA at the GABA receptors, specifically the GABAA receptor subtype. They achieve this by binding to a specific site on the GABAA receptor, which enhances the receptor's affinity for GABA. This leads to an increased frequency of chloride channel opening when GABA binds, resulting in greater inhibitory effects in the central nervous system. The enhancement of GABAergic activity promotes sedation, anxiolysis, muscle relaxation, and anticonvulsant effects, which are characteristic of benzodiazepines.

While barbiturates also enhance GABAergic activity, they do so differently by increasing the duration that the chloride channels remain open, and thus are often associated with a higher risk of respiratory depression and overdose compared to benzodiazepines. Antidepressants, typically used for mood disorders, generally do not directly enhance GABAergic activity. Stimulants primarily work by increasing the release of neurotransmitters like dopamine and norepinephrine, rather than enhancing GABA activity. Therefore, the action of benzodiazepines makes them distinct among the given options for their specific role in increasing GABA's effect at its receptors.

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