Which irreversible neurodegenerative disorder leads to a decline in daily living activities and cognitive abilities?

The correct answer highlights Alzheimer's disease, which is characterized by a progressive decline in cognitive function and daily living activities. This neurodegenerative disorder mainly affects older adults and is associated with various pathophysiological changes in the brain, including the formation of amyloid plaques and neurofibrillary tangles. Over time, these changes lead to significant impairments in memory, language, and reasoning, ultimately preventing individuals from performing everyday tasks.

In Alzheimer's disease, the decline in cognitive abilities commonly manifests as forgetfulness initially, which can advance to severe memory loss and disorientation. As the disease progresses, individuals may struggle with language, have difficulty recognizing familiar faces, and may require assistance with daily activities such as dressing, bathing, and managing finances. This gradual deterioration contributes to a substantial decline in the quality of life for both patients and their caregivers.

While the other conditions listed also involve neurodegenerative processes, they do not typically present the same progressive decline specifically associated with cognitive impairment and daily living activity loss. For instance, Parkinson's disease primarily affects movement and can lead to cognitive decline, but the hallmark is motor symptoms like tremors and rigidity. Huntington's disease includes cognitive decline, but it is primarily characterized by chorea and psychiatric symptoms. Multiple sclerosis is an