Which class of drugs stimulates the release of norepinephrine and dopamine while blocking their reuptake?

Amphetamines are indeed known for their unique mechanism of action, which involves both stimulating the release of norepinephrine and dopamine and concurrently blocking their reuptake. This dual action contributes to the heightened levels of these neurotransmitters in the synaptic cleft, leading to increased sympathetic activity and enhanced mood, energy, and alertness.

This release and reuptake inhibition create a powerful stimulant effect, which is why amphetamines are frequently used in the treatment of conditions like ADHD and narcolepsy, as well as sometimes being misused for their euphoric effects. The ability to boost norepinephrine and dopamine levels is pivotal in many neuropharmacological outcomes associated with these drugs.

Other classes, such as antidepressants, primarily focus on increasing neurotransmitter levels but do so by different mechanisms such as inhibiting monoamine oxidase or selectively blocking reuptake without the stimulant aspect present in amphetamines. Barbiturates and tranquilizers generally act as depressants on the central nervous system, further differentiating them from the stimulating effects seen with amphetamines. Therefore, the characteristics and mechanisms attributed to amphetamines distinctly align with the question's requirements.