What is the primary concern with prolonged use of propofol?

The primary concern with prolonged use of propofol is related to microbial growth. Propofol is formulated in a lipid emulsion, which provides an environment conducive to the growth of bacteria if not handled properly. Once opened, the potential for contamination increases, especially if the vial is not used within a certain time frame or if it is stored improperly. Inadequate sterilization techniques or improper handling can lead to infections, which can be life-threatening.

The formulation's nature means that healthcare providers must adhere to strict protocols regarding the storage and use of propofol to mitigate this risk. While concerns such as tolerance development, risk of allergic reactions, and potential for addiction are also valid, they are not the primary issue associated with the prolonged administration of propofol in clinical settings. These factors do have relevance in specific contexts but do not carry the same immediate infection risk posed by microbial growth.