What is a notable adverse effect associated with triazolam?

Triazolam, a benzodiazepine used primarily for the management of insomnia, is particularly associated with anterograde amnesia as a notable adverse effect. This phenomenon occurs because triazolam enhances the effects of gamma-aminobutyric acid (GABA) at the GABA-A receptor, which plays a crucial role in the consolidation of memories. As a result, while individuals may be able to form memories prior to taking the medication, they may struggle to remember events that occur after dosing, particularly if the drug's effects are still active.

This amnesic effect can lead to significant challenges, especially given that it can occur even at therapeutic doses, which is particularly concerning in a population using the drug for sleep disturbances where events such as complex actions or behaviors might occur without conscious recollection.

The options related to respiratory depression, cardiovascular issues, or severe headaches are not typically the primary concerns associated with triazolam, thereby solidifying anterograde amnesia as a key adverse effect that healthcare providers should monitor when prescribing this medication.