What is a notable adverse effect associated with propofol administration?

The notable adverse effect associated with propofol administration is microbial growth. Propofol is formulated in a lipid emulsion that can provide an environment conducive to microbial proliferation if not handled or stored properly. This concern is particularly relevant because propofol is often administered in a setting where sterility is critical, such as in surgical or intensive care environments.

Inappropriate handling, such as using outdated vials or leaving opened vials at room temperature, can lead to contamination, which may cause serious infections in patients receiving the drug. It’s essential for healthcare providers to adhere strictly to guidelines for the storage and administration of propofol to mitigate this risk.

Prolonged sedation and cardiac arrest can occur with propofol, but these are less specifically tied to its formulation and more a consequence of the pharmacodynamic effects of an anesthetic agent. Increased blood pressure is not typically a characteristic effect of propofol; in fact, it often causes hypotension. Therefore, understanding the risk of microbial growth highlights a specific safety concern that should always be considered during its administration.