Apomorphine is considered safe to administer to patients with which of the following conditions?

Apomorphine is primarily known for its use as a dopaminergic agent, especially in the treatment of Parkinson's disease and as an emetic in specific contexts. In this case, the administration of apomorphine would be considered safe for patients with psychosis under certain conditions, particularly when including its therapeutic effect in enhancing dopaminergic activity.

Psychosis, which is characterized by a disconnection from reality that may involve hallucinations or delusions, can sometimes be managed with dopaminergic medications. Apomorphine acts as a dopamine agonist and can, therefore, help alleviate motor symptoms associated with Parkinson's disease in patients who may also experience psychotic symptoms as a side effect of their primary treatment.

In contrast, apomorphine is less suitable for individuals with severe depression, severe anxiety, or insomnia, as these conditions may be exacerbated by increased dopaminergic activity or could lead to adverse reactions due to the complex interplay of neurotransmitters in the CNS. Hence, the choice of apomorphine for patients with psychosis is based on its potential benefits in managing specific symptoms of Parkinson's disease without significantly worsening their psychiatric condition.