Anticonvulsants increase the action of which neurotransmitter?

Prepare for the Pharmacology III – CNS Module Exam. Enhance your knowledge with detailed questions and thorough explanations. Excel in your exam!

Anticonvulsants primarily work by enhancing the action of Gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the central nervous system. By increasing GABA activity, these medications effectively raise the threshold for neuronal excitability, reducing the likelihood of seizure activity.

GABA exerts its effects by binding to GABA receptors on neurons, leading to increased chloride ion influx and hyperpolarization of the cell membrane. This hyperpolarization makes neurons less likely to fire and helps to stabilize electrical activity in the brain. The ability of anticonvulsants to modulate GABAergic transmission is a crucial mechanism in their action against seizures.

The other neurotransmitters listed, such as dopamine, norepinephrine, and serotonin, are involved in different pathways and affect mood, cognition, and overall arousal rather than having a direct role in the modulation of seizure activities as GABA does. Therefore, GABA's involvement is what makes it the correct answer in the context of how anticonvulsants function.

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